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HIV Vaccine Development: Related Resources
Content reviewed June 2013
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arrow imageUpdates
arrow imageRelated Knowledge Base Chapters
arrow imageJournal Articles
arrow imageGuidelines and Best Practices
arrow imageConference Reports and Proceedings
arrow imagePresentations, Interviews, and Roundtable Discussions
arrow imageResearch Summaries
arrow imageOnline Books and Chapters
arrow imageClinician Support Tools
arrow imageSlide Sets
arrow imageLinks
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Updates
decorative spacerNIH Discontinues Immunizations in HIV Vaccine Study
Statement from the National Institutes of Health regarding termination of the HVTN 505 clinical trial; April 25, 2013.
decorative spacerFailure of latest HIV vaccine test: a 'huge disappointment'
News article from NPR; April 26, 2013.
Related Knowledge Base Chapters
decorative spacerAssays to Detect Host Immune Responses to HIV
Helen Horton, M. Juliana McElrath, July 2003.
decorative spacerPolicy Issues in AIDS Vaccine Development
Chris Collins, February 2001.
Journal Articles
decorative spacerA brief history of the global effort to develop a preventive HIV vaccine
Esparza J. Vaccine. 2013 May 21.
decorative spacerHarnessing CD4+ T cell responses in HIV vaccine development
Streeck H, D'Souza MP, Littman DR, et al. Nat Med. 2013 Feb;19(2):143-9.
decorative spacerAccelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines
Koff WC, Russell ND, Walport M, et al.
decorative spacerRecent advances in research of HIV infection: implications of viral and host genetics on treatment and prevention
Haaland RE, Johnson JA, Tang J. Public Health Genomics. 2013;16(1-2):31-6.
decorative spacerHIV vaccine development: strategies for preclinical and clinical investigation
Shapiro SZ. AIDS Res Hum Retroviruses. 2013 Mar 8.
decorative spacerIn pursuit of an HIV vaccine: designing efficacy trials in the context of partially effective non-vaccine prevention modalities
Janes H, Gilbert P, Buchbinder S, et al. AIDS Res Hum Retroviruses. 2013 Apr 19.
decorative spacerThe Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120
Karasavvas N, Billings E, Rao M, et al. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1444-57.
decorative spacerRational design of vaccines for AIDS and influenza
Nabel GJ. Trans Am Clin Climatol Assoc. 2012;123:9-15; discussion 15-6.
decorative spacerHIV-1 vaccine trials: evolving concepts and designs
Sanou MP, De Groot AS, Murphey-Corb M, et al. Open AIDS J. 2012;6:274-88.
decorative spacerHIV vaccines: progress to date.
Munier CM, Andersen CR, Kelleher AD. Drugs. 2011 Mar 5;71(4):387-414.
Guidelines and Best Practices
decorative spacerGood Participatory Practice: Guidelines for Biomedical HIV Prevention Trials, 2011
UNAIDS. Guidelines to complement the companion document Ethical Considerations in Biomedical HIV Prevention Trials. [PDF, 3.1MB]
decorative spacerEthical Considerations in Biomedical HIV Prevention Trials
UNAIDS, 2007 (additional guidance point added in 2012). [PDF, 868K]
decorative spacerDeclaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects
World Medical Association, June 1964 (periodically amended).
Conference Reports and Proceedings
decorative spacerAIDS Vaccine Conference 2012
Conference page with program, abstracts, and webcasts. September 9-12, 2012; Boston.
Presentations, Interviews, and Roundtable Discussions
decorative spacerHVTN Trial Results and Implications for Future Research
A webinar featuring investigators Scott Hammer and Madgalena Sobieszczyk, who discuss the results of the HVTN 505 AIDS vaccine clinical trial and take questions. April 30, 2013.
Research Summaries
decorative spacerHIV Preventive Vaccine Clinical Trials
List from AIDSinfo.
decorative spacerHIV Therapeutic Vaccine Clinical Trials
List from AIDSinfo.
Online Books and Chapters
decorative spacerImmunobiology: The Immune System in Health and Disease
Charles Janeway, Paul Travers, Mark Walport, Mark Shlomchik, eds. Garland Science Publishing; 2001.
Clinician Support Tools
decorative spacerPreventative HIV Vaccine Trials
A chart from AVAC listing the ongoing vaccine trials, with key information such as phase, regimen, current status, and number of enrollees; April 2013. [PDF, 275KB]
Slide Sets
decorative spacerAIDS Vaccines: The Basics
An introductory slide set with basic concepts, an overview of research status and recent developments; AVAC; April 2013. [PPT, 4.82MB]
decorative spacerAIDS Vaccines: Then and Now
Graphical comparisons of numbers of AIDS vaccine trial sites, participants, and investment over the years; AVAC; May 2012. [PPT, 2.73MB]
Links
Organizations
Research
decorative spacerBill and Melinda Gates Foundation: Global Health
Funds HIV/AIDS vaccine development initiatives.
decorative spacerFDA Center for Biologics Evaulation and Research
(CBER) U.S. regulatory agency that oversees vaccine products.
decorative spacerGlobal HIV Vaccine Enterprise
An alliance of independent organizations around the world dedicated to accelerating the development of a preventive HIV vaccine.
decorative spacerHarvard AIDS Institute
Vaccine research page.
decorative spacerHIV Vaccine Trials Network
(HVTN) International NIAID-sponsored preventive vaccine trials sites network.
decorative spacerIAVI Report Online
Newsletter on international AIDS vaccine research.
decorative spacerNIH Vaccine Research Center
Focus of research is on the development of vaccines for AIDS.
decorative spacerPasteur Institute
A leading HIV vaccine research organization in France.
decorative spacerSouth African AIDS Vaccine Initiative
(SAAVI) A national body coordinating the research, development and testing of HIV/AIDS vaccines in South Africa.
decorative spacerTestes para Vacinas Anti-HIV
Portuguese-language web site provides information about HIV vaccines for the general public, and offers volunteers the opportunity to sign up for vaccine trials at the University of São Paulo, Brazil.
decorative spacerU.S. Military HIV Research Program
The U.S. Military HIV Research Program encompasses Army, Navy and Air Force medical centers, hospitals, and research institutes in the U.S. and around the globe. Research focus includes vaccine development and clinical trials.
decorative spacerU.S. National Institute of Allergy and Infectious Diseases, Division of AIDS
Part of the U.S. National Institutes of Health. Premier public research institution funding basic and applied research on AIDS vaccine development. Web site includes comprehensive overview of HIV/AIDS vaccine discovery, plus information on research funding opportunities and vaccine-related links.
decorative spacerVaccine Research Center
Part of the NIH's National Institute of Allergy and Infectious Diseases (NIAID), the Dale and Betty Bumpers Vaccine Research Center (VRC) was established to facilitate research in vaccine development.
Advocacy
decorative spacerAIDS Vaccine Advocacy Coalition
(AVAC) Advocacy for developing HIV/AIDS vaccines. Site features Vaccine handbook, news articles, official reports, FAQs, and activist manifestos.
decorative spacerCapital Area Vaccine Effort
A volunteer panel of individuals from the general public and communities affected by AIDS. Assists and advises vaccine trials in the metropolitan Washington, DC area.
decorative spacerGlobal Alliance for Vaccines and Immunization
Works to expand access to existing vaccines in the developing world and accelerate research on needed vaccines, including HIV vaccines.
decorative spacerInternational AIDS Vaccine Initiative
(IAVI) Works to speed the development and distribution of preventive AIDS vaccines by funding research, mobilizing support through advocacy and education, and encouraging private sector participation in AIDS vaccine development.
decorative spacerNational AIDS Trust (UK)
UK's leading policy development and advocacy AIDS organisation. Includes a prevention technologies annual update.
decorative spacerWHO-UNAIDS HIV Vaccine Initiative
(HVI) Advocacy, information, education, and policy dialogue.
Vaccine Company Pages
decorative spacerAlphaVax
VEE product.
decorative spacerBavarian Nordic
Poxvirus (MVA) vector.
decorative spacerChiron
DNA and peptide approaches.
decorative spacerCrucell
Adenoviral vectors.
decorative spacerGeovax
DNA plasmids and MVA vectors.
decorative spacerProgenics Pharmaceuticals, Inc.
Monoclonal antibodies and gp 140.
decorative spacerVaxGen
AIDSVAX gp120 subunit.
Clinical Trial Databases
decorative spacer AIDSinfo Vaccine Information
A service of the U.S. Department of Health and Human Services. Includes searchable listings of clinical trials for preventive and therapeutic HIV vaccines, as well as a glossary, HIV vaccine news, and links to related web sites.
decorative spacerHIV/SIV Vaccine Trials Database
A project of the Los Alamos National Laboratory.
decorative spacerInternational AIDS Vaccine Initiative (IAVI)
Works to speed the development and distribution of preventive AIDS vaccines by funding research, mobilizing support through advocacy and education, and encouraging private sector participation in AIDS vaccine development.
Document Collections
decorative spacerFDA Center for Biologics Evaulation and Research (CBER)
Vaccine publication guidance page.
decorative spacerHIV and Hepatitis.com
Reports on HIV vaccines.
decorative spacerThe Body
Compilation of HIV vaccine articles.

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